![]() We report for the first time on the metalation pathways of As 3+ binding to apo-MT3 under physiological conditions, yielding the absolute binding constants (logK n, n=1-6) for each sequential As 3+ binding event: 10.20, 10.02, 9.79, 9.48, 9.06, and 8.31 M -1. Central nervous system expression of MT isoform 3 (MT3) is thought to be neuroprotective. In human physiology, one response to toxic metals is through coordination with the metallochaperone metallothionein (MT). Human exposure to arsenic occurs worldwide from contaminated drinking water. ![]() ![]() ![]() Arsenic poisoning is of great concern with respect to its neurological toxicity, which is especially significant for young children. ![]()
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